Key result
Activation of the aortic baroreflex alone attenuated muscle sympathetic nerve activity by 73%, which was not significantly different from the 65% attenuation seen with combined activation.
Why the study?
Does aortic baroreflex activation alone compared to combined aortic and carotid baroreflex activation differentially control muscle sympathetic nerve activity during elevated blood pressure in normal men?
Population
15 normal men (8 in group I, 7 in group II)
Comparison
Intravenous infusion of phenylephrine with… vs Intravenous infusion of phenylephrine alone
Design
Other
Authors
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Provides mechanistic insight into CBR vs ABR control of MSNA; leaves open clinical translation to hypertension.
Does aortic baroreflex activation alone compared to combined aortic and carotid baroreflex activation differentially control muscle sympathetic nerve activity during elevated blood pressure in normal men?
Absolute Event Rate: 48.6% vs 84.5%
p-value: p=NS
Aortic baroreflexes appear to dominate the control of muscle sympathetic nerve activity during sustained elevation of blood pressure in normal men.
Sanders et al. (1988) studied Healthy volunteers (n=15). Phenylephrine infusion with superimposed external neck pressure (aortic baroreflex activation alone) vs. Phenylephrine infusion alone (combined aortic and carotid baroreflex activation) was evaluated on Muscle sympathetic nerve activity (MSNA) in units (p=NS). Activation of the aortic baroreflex alone attenuated muscle sympathetic nerve activity by 73%, which was not significantly different from the 65% attenuation seen with combined activation.
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