Key result
Complex transposition of the great arteries was associated with a significantly lower freedom from surgical reoperation at 15 years compared to simple transposition (91% vs 98.3%).
Why the study?
Long-term outcomes after the arterial switch operation for transposition of the great arteries, along with anatomical and clinical factors associated with adverse outcomes comparing simple and complex anatomy, needed evaluation.
Does the arterial switch operation provide excellent long-term survival and low reintervention rates in patients with simple versus complex transposition of the great arteries?
Population
233 patients who underwent arterial switch operation (158 simple TGA and 75 complex TGA)
Comparison
Simple TGA vs complex TGA
Design
Single-centre cohort study
Follow-up
Up to 15 years
Authors
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Closer follow-up may be warranted after ASO in complex TGA; leaves open whether coronary anatomy independently drives late reoperation.
Cohort (n=233)
No
Does the arterial switch operation provide excellent long-term survival and low reintervention rates in patients with simple versus complex transposition of the great arteries?
Absolute Event Rate: 91% vs 98.3%
p-value: p=0.039
The arterial switch operation provides excellent long-term survival and low reintervention rates, though complex anatomy and specific coronary patterns increase the risk of mortality and reoperation.
Orioli et al. (2025) conducted a cohort in Transposition of the great arteries (n=233). Complex transposition of the great arteries vs. Simple transposition of the great arteries was evaluated on Freedom from surgical reoperation at 15 years (p=0.039). Complex transposition of the great arteries was associated with a significantly lower freedom from surgical reoperation at 15 years compared to simple transposition (91% vs 98.3%).