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January 28, 2010Acta PaediatricaOpen Access

Heart rate variability (HRV) in adolescent females with anxiety disorders and major depressive disorder

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Why the study?

Do anxiety disorders and/or major depressive disorder, and SSRI use, affect heart rate variability in adolescent females?

Population

134 adolescent females, including 69 psychiatric patients with anxiety disorders and/or major depressive…

Comparison

Presence of anxiety disorders and/or major… vs Healthy controls

Design

Case-control

Authors

EOErik OlssonESEva SerlachiusMEMats Ericson

Discussion

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Overview

May warrant HRV monitoring in adolescent females with anxiety or depression; leaves open SSRI contribution pending prospective data.

Structured PICO

Do anxiety disorders and/or major depressive disorder, and SSRI use, affect heart rate variability in adolescent females?

P
Population
134 adolescent females, including 69 psychiatric patients with anxiety disorders (AD) and/or major depressive disorder (MDD) (mean age 16.8 years) from 13 out-patient clinics, and 65 healthy controls (mean age 16.5 years).
I
Intervention
Presence of anxiety disorders (AD) and/or major depressive disorder (MDD), and use of selective serotonin reuptake inhibitors (SSRI)
C
Comparator
Healthy controls
O
Outcome
Heart rate variability (HRV) including high frequency (HF), low frequency (LF), and standard deviation of inter beat intervals (SDNN) measured during 4 min in sitting positionsurrogate

Adolescent females with anxiety or depressive disorders have reduced heart rate variability compared to healthy controls, which is partially explained by SSRI medication use.

Cite This Study

Olsson et al. (2010) studied this question.

synapsesocial.com/papers/6a809d2b73f13514bdeed23bhttps://doi.org/10.1111/j.1651-2227.2009.01657.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Major depression and cardiac autonomic control1997 · 121 citations
  2. 2Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales.1995 · 1,230 citations