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April 1, 2017Pulmonary CirculationOpen Access

The SU/hyp model showed a significantly lower ratio of vascular volume to total lobe volume compared with control in the distal lobes (inferior: 0.23 [0.21–0.30] versus 0.35 [0.27–0.43], P = 0.02).

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Population

Sprague-Dawley rats

Comparison

Subcutaneous injection of vascular endothelial… vs Control rats

Design

Preclinical

Follow-up

3 weeks

Authors

EFErin M. FaightKVKostas VerdelisLZLee Zourelias

Discussion

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Overview

Highlights spatial heterogeneity of vascular remodeling in pulmonary arterial hypertension; extends understanding of preclinical models while leaving open whether.

Structured PICO

P
Population
Sprague-Dawley rats
I
Intervention
Subcutaneous injection of vascular endothelial growth factor receptor blocker (Sugen 5416) and subsequent exposure to chronic hypoxic conditions (10% O2) for three weeks (SU/hyp model)
C
Comparator
Control rats
O
Outcome
Ratio of vascular volume to total lobe volume measured by microCT 3D morphometry analysissurrogate

MicroCT analysis reveals that vascular remodeling in the Sugen-hypoxic rat model of pulmonary arterial hypertension is extensive but lobe-dependent, primarily affecting the distal lobes.

Cite This Study

Faight et al. (2017) studied this question.

synapsesocial.com/papers/6a80ac891024bacc9692c3ddhttps://doi.org/10.1177/2045893217709001
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