4-Aminoalkylquinolines as Potent Antitubercular Agents Targeting the Cytochrome bc ₁ Complex

complex. Single-crystal X-ray diffraction confirmed the structure of a representative compound. Selected molecules showed favorable selectivity in Vero and HepG2 cells and limited activity against non-mycobacterial bacteria. In vitro ADME profiling revealed pH-dependent solubility, good permeability, and rapid metabolic turnover. Zebrafish assays showed no detectable cardiac effects up to 0.3 μM. Overall, this chemotype represents a promising scaffold for antitubercular agents targeting mycobacterial respiration.