Population
Isolated middle cerebral arteries (MCAs) from fructose-fed insulin-resistant (IR) rats and control rats (n=23)
Comparison
Fructose-induced insulin resistance vs MCAs from control rats
Design
Preclinical
Authors
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Insulin resistance may impair cerebral endothelial function; animal data leaves open relevance to human cerebrovascular risk.
Insulin resistance impairs endothelium-dependent dilation in cerebral arteries primarily due to a defect in cyclooxygenase-mediated pathways, while nitric oxide-mediated dilation remains intact.
Erdös et al. (2002) studied this question.
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