Why the study?
Does inhibition of nitric oxide biosynthesis and cyclic GMP formation attenuate nerve-evoked relaxation in human cavernosal smooth muscle?
Population
Isolated preparations of cavernosal smooth muscle from human penis
Comparison
Nitric oxide-synthase inhibitor L-NG-nitro… vs D-NG-nitro arginine, L-arginine, D-arginine, or…
Design
Preclinical
Authors
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Supports NO mediation of cavernosal relaxation in animals; leaves open human translation and clinical validation.
Does inhibition of nitric oxide biosynthesis and cyclic GMP formation attenuate nerve-evoked relaxation in human cavernosal smooth muscle?
Non-adrenergic, non-cholinergic nerve-evoked relaxation of human cavernosal smooth muscle is mediated by nitric oxide or a NO-like substance.
Pickard et al. (1991) studied this question.
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