Why the study?
Do collagen and platelet-activating factor inhibit adenylate cyclase activity in equine platelets?
Do collagen and platelet-activating factor inhibit adenylate cyclase activity in equine platelets?
This preclinical study demonstrates that collagen and platelet-activating factor stimulate equine platelet aggregation by inhibiting adenylate cyclase activity.
Answers are grounded in this paper and cite their sources.
Does not support clinical translation; leaves open whether PAF antagonism modulates platelets in other species.
Equine platelet aggregation was stimulated by collagen fibres or platelet-activating factor. The action of both ligands was blocked by forskolin or prostaglandin E(1) agents which are known to activate adenylate cyclase. Equine platelet membranes were found to contain adenylate cyclase activity which was inhibited in dose-dependent fashion by both collagen and platelet-activating factor. Platelet-activating factor-induced inhibition was antagonised by WEB2086.
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Farndale et al. (1996) studied this question.
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