October 1, 1994Journal of Veterinary Pharmacology and Therapeutics

The effects of aspirin and paracetamol on the aggregation of equine blood platelets

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Why the study?

Does aspirin or paracetamol affect the aggregation of equine blood platelets?

Population

Equine blood platelets in citrated platelet-rich plasma

Design

Preclinical

Authors

MHM. F. HeathUniversity of Cambridge RERichard J. EvansWellington Hospital APAlastair W. PooleUniversity of Bristol

Discussion

Member takes

Implication

TxA2 blockade insufficient for full equine platelet inhibition; leaves open alternative pathways as therapeutic targets in horses.

Structured PICO

Does aspirin or paracetamol affect the aggregation of equine blood platelets?

Population

Equine blood platelets in citrated platelet-rich plasma

Intervention

Pre-treatment with aspirin (1 mmol/l) or paracetamol (1.3 mmol/l)

Outcome

Platelet shape change and aggregation in response to arachidonic acid, U44069, adenosine 5'-diphosphate, platelet-activating factor or collagensurrogate

Thromboxane A2 generation appears to be of minor importance in the aggregation of equine platelets and is not a significant mediator of irreversible aggregation.

Cite This Study

Heath et al. (1994) studied this question.

synapsesocial.com/papers/6a87dab49f534feb2aad2623 https://doi.org/10.1111/j.1365-2885.1994.tb00262.x

View Full Paper

Ask AI

Bookmark

The effects of aspirin and paracetamol on the aggregation of equine blood platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The effects of aspirin and paracetamol on the aggregation of equine blood platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider