Why the study?
Various genetic factors influence warfarin maintenance dose, prompting evaluation of the impact of CYP2C19 polymorphisms.
Do CYP2C19 gene polymorphisms reduce warfarin maintenance dose requirements in patients receiving warfarin?
Do CYP2C19 gene polymorphisms reduce warfarin maintenance dose requirements in patients receiving warfarin?
CYP2C19 rs4986893 and rs3814637 polymorphisms are associated with significantly lower warfarin maintenance dose requirements, highlighting their potential role in pharmacogenetic-guided dosing.
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May aid genotype-guided dosing but should not yet change practice; confirms CYP2C19 links and leaves open algorithm updates.
Wang et al. (2022) studied this question.
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