Why the study?
Do GGCX gene polymorphisms affect the mean daily warfarin dose requirement in patients taking warfarin?
Do GGCX gene polymorphisms affect the mean daily warfarin dose requirement in patients taking warfarin?
The GGCX rs11676382 polymorphism is associated with a significantly lower warfarin dose requirement, particularly in Caucasian populations, highlighting its potential role in pharmacogenetic-guided dosing.
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May inform warfarin dosing in G carriers; extends pharmacogenetic models but requires RCT validation before clinical use.
Sun et al. (2015) studied this question.
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