Key result
VKORC1 gene polymorphisms significantly impacted warfarin dosage, with Asian patients ≤60 years requiring 22-39% higher doses and Caucasian patients >60 years requiring 24-39% lower doses.
Why the study?
Do VKORC1 gene polymorphisms affect warfarin maintenance dosage across different age and ethnic groups?
Meta-Analysis
Do VKORC1 gene polymorphisms affect warfarin maintenance dosage across different age and ethnic groups?
p-value: p=<0.05
VKORC1 gene polymorphisms significantly impact warfarin maintenance dosage requirements, with effects varying considerably by age and ethnicity.
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Supports VKORC1-guided warfarin dosing with age-ethnicity adjustments; extends pharmacogenomic evidence for precision anticoagulation.
Tang et al. (2016) conducted a meta-analysis in Patients requiring warfarin. VKORC1 gene polymorphisms vs. Other genotypes and age groups was evaluated on Warfarin maintenance dosage (p=<0.05). VKORC1 gene polymorphisms significantly impacted warfarin dosage, with Asian patients ≤60 years requiring 22-39% higher doses and Caucasian patients >60 years requiring 24-39% lower doses.
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