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July 25, 2017PLoS ONEOpen Access

The relationship between coronary artery distensibility and fractional flow reserve

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Why the study?

Does coronary arterial distensibility independently predict fractional flow reserve (FFR) in patients with coronary artery disease?

Population

104 consecutive patients requiring FFR measurement of a single target lesion at two tertiary referral…

Design

Cross-sectional, Operator measuring distensibility was blinded to FFR results.

Authors

AYA. YongInterventional CardiologyAJAshkan JavadzadeganThe University of SydneyWFWilliam F. FearonInterventional Cardiology

Discussion

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Implication

Coronary arterial distensibility at the lesion site is a novel, independent determinant of FFR, contributing to the discordance between anatomical and functional assessment of stenosis severity.

Structured PICO

Does coronary arterial distensibility independently predict fractional flow reserve (FFR) in patients with coronary artery disease?

P
Population
104 consecutive patients requiring FFR measurement of a single target lesion (mean age 63, 78.8% male) at two tertiary referral institutions, and 26 'in silico' models of human coronary arteries.
I
Intervention
Assessment of coronary arterial distensibility (DistensibilityMLA and DistensibilityRef) using 3D quantitative coronary angiography and computational fluid dynamics (CFD) modeling.
O
Outcome
Fractional flow reserve (FFR) and its correlation with coronary arterial distensibility.surrogate

Coronary arterial distensibility at the lesion site is a novel, independent determinant of FFR, contributing to the discordance between anatomical and functional assessment of stenosis severity.

Limitations

  • Limitations in image quality

Cite This Study

Yong et al. (2017) studied this question.

synapsesocial.com/papers/6a80d072da9cafc35e3366e1https://doi.org/10.1371/journal.pone.0181824
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired coronary artery distensibility is an endothelium‐dependent process and is associated with vulnerable plaque composition2014 · 22 citations
  2. 2Coronary artery compliance and adaptive vessel remodelling in patients with stable and unstable coronary artery disease2000 · 53 citations
  3. 3Multiphysics Simulation of Blood Flow and LDL Transport in a Porohyperelastic Arterial Wall Model2006 · 80 citations
  4. 4Effect of Low-and High-Dose Atorvastatin on Carotid Artery Distensibility Using Carotid Magnetic Resonance Imaging ^|^mdash;A Post-Hoc Sub Group Analysis of ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) Study2012 · 15 citations
  5. 5Prognostic Value of Fractional Flow Reserve2014 · 632 citations