Coronary artery compliance and adaptive vessel remodelling in patients with stable and unstable coronary artery disease
Why the study?
Do patients with unstable coronary syndromes show accentuated compensatory vessel enlargement and increased coronary artery distensibility compared with patients with stable angina?
Population
46 patients with coronary artery disease, comprising 23 patients with unstable coronary syndromes and 23…
Comparison
Intravascular ultrasound assessment of the… vs Patients with stable angina matched for age…
Design
Case-control
Authors
Discussion
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Implication
May indicate distinct vessel properties in unstable syndromes; hypothesis-generating for vulnerability markers, needs prospective validation.
Structured PICO
Do patients with unstable coronary syndromes show accentuated compensatory vessel enlargement and increased coronary artery distensibility compared with patients with stable angina?
P
Population
46 patients with coronary artery disease, comprising 23 patients with unstable coronary syndromes (10 with non-Q wave myocardial infarction and 13 with unstable angina) and 23 patients with stable angina matched for age, sex, and target vessel.
I
Intervention
Intravascular ultrasound (IVUS) assessment of the culprit lesion before intervention.
C
Comparator
Patients with stable angina matched for age, sex, and target vessel.
O
Outcome
Vessel cross sectional area (VA), lumen area (LA), plaque area, remodelling index, distensibility index, and stiffness index beta at the lesion site and reference segments.surrogate
Patients with unstable coronary syndromes exhibit greater compensatory vessel enlargement (positive remodelling) and increased coronary artery distensibility compared to those with stable angina.
Cite This Study
Allen Jeremias (2000) studied this question.