May 1, 1996European Heart Journal
Interventional cardiology: Differences in the morphology of unstable and stable coronary lesions and their impact on the mechanisms of angioplasty. An in vivo study with intravascular ultrasound
Why the study?
Do unstable and stable coronary lesions have different morphologies on intravascular ultrasound, and does this influence the mechanism of balloon angioplasty?
Population
33 patients undergoing single lesion percutaneous transluminal coronary angioplasty.
Comparison
Intravascular ultrasound assessment of unstable… vs Intravascular ultrasound assessment of stable…
Design
Cohort
Authors
Discussion
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Implication
IVUS morphology may differentiate angioplasty mechanisms by lesion stability; supports mechanistic insights but leaves open impact on outcomes.
Structured PICO
Do unstable and stable coronary lesions have different morphologies on intravascular ultrasound, and does this influence the mechanism of balloon angioplasty?
P
Population
33 patients (15 with stable and 18 with unstable lesions) undergoing single lesion percutaneous transluminal coronary angioplasty.
I
Intervention
Intravascular ultrasound (IVUS) assessment of unstable coronary lesions before and after balloon angioplasty
C
Comparator
Intravascular ultrasound (IVUS) assessment of stable coronary lesions before and after balloon angioplasty
O
Outcome
Morphology of lesions before intervention and mechanisms of angioplasty (vessel stretch, lesion remodelling, and lesion tears) determined by comparing pre- and post-interventional morphology and dimensionssurrogate
Intravascular ultrasound demonstrates that unstable coronary lesions have distinct morphological markers suggestive of mural thrombus and respond to angioplasty primarily via lesion remodelling, unlike stable lesions which respond via vessel stretch.
Cite This Study
Kearney et al. (1996) studied this question.