ACTH Producing Matastases from Carcinoma of the Esophagus

Case Studies1 May 1965ACTH Producing Matastases from Carcinoma of the EsophagusFRANCIS N. LOHRENZ, M.D., G. STANLEY CUSTER, M.D.FRANCIS N. LOHRENZ, M.D.Search for more papers by this author, G. STANLEY CUSTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1017 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of Cushing's syndrome with "nonendocrine" tumors has been discussed in several recent reviews (1-3). The most frequent sites of primary tumor have been the lungs, thymus, or pancreas. Meador and associates (4) in 1962 demonstrated adrenocorticotropin-like activity in five patients with hypokalemia, hypercorticism, and bilateral adrenal hyperplasia associated with neoplasms not of pituitary or adrenal origin. Adrenocorticotropic hormone (ACTH)-like material was present in the primary tumor, in metastatic tissue, and in the plasma of each patient. Liddle and associates (5) subsequently demonstrated active ACTH-like material in the primary and metastatic tumor of 13 patients. They suggested a change...References1. ALLOTTSKELTON ENMO: Increased adrenocortical activity associated with malignant disease. Lancet 2: 278, 1960. CrossrefMedlineGoogle Scholar2. RIGGSSPRAGUE BLRG: Association of Cushing's syndrome and neoplastic disease. Arch. Intern. Med. (Chicago) 108: 841, 1961. CrossrefMedlineGoogle Scholar3. GREENBERGDIVERTIEWOOLNER EMBLB: A review of unusual systemic manifestations associated with carcinoma. Amer. J. Med. 36: 106, 1964. CrossrefMedlineGoogle Scholar4. MEADORLIDDLEISLANDNICHOLSONLUCASNUCKTONLUETSCHER CKGWDPWECPJGJA: Cause of Cushing's syndrome in patients with tumors arising from "nonendocrine" tissue. J. Clin. Endocr. 22: 693, 1962. CrossrefMedlineGoogle Scholar5. 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NICHOLSWARRENMANTZ JJCFA: ACTH-like excretion from carcinoma of the ovary. JAMA 182: 713, 1962. CrossrefMedlineGoogle Scholar12. POUTASSEHIGGINS EFCC: Surgery of the adrenal gland for Cushing's syndrome. J. Urol. 70: 129, 1953. CrossrefMedlineGoogle Scholar13. BRICKNERLYONSLANDAU PWMSJ: Cushing's syndrome associated with nonendocrine neoplasms. Amer. J. Med. 31: 632, 1961. CrossrefMedlineGoogle Scholar14. MATYSNOHELVOJTISEKKUDRMANNSTARKA ZBVJL: Benign adenoma of the left adrenal with tuberculosis of the right adrenal in a patient with Cushing's syndrome and adenocarcinoma of the large intestine. Cas. Lek. Cesk. 102: 636, 1963. MedlineGoogle Scholar15. ANDERSEN OS: A graphic presentation of changes of the acid-base status. Scand. J. Clin. Lab. Invest. 12: 311, 1960. CrossrefMedlineGoogle Scholar16. SILBERPORTER RHCK: The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma. J. Biol. Chem. 210: 923, 1954. CrossrefMedlineGoogle Scholar17. DREKTERHEISLERSCISMSTERNPEARSONMCGAVACK IJAGRSSTH: The determination of urinary steroids. I. The preparation of pigment-free extracts and a simplified procedure for the estimation of total 17-ketosteroids. J. Clin. Endocr. 12: 55, 1952. CrossrefMedlineGoogle Scholar18. PETERSONKARRERGUERRA REASL: Evaluation of Silber-Porter procedure for determination of plasma hydrocortisone. Analyt. Chem. 29: 144, 1957. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Marshfield, WisconsinFrom the Marshfield Clinic and Marshfield Clinic Foundation for Medical Research and Education, Marshfield, Wisc.Requests for reprints should be addressed to Francis N. Lohrenz, M.D., Marshfield Clinic, 630 South Central Ave., Marshfield, Wisc. 54449. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByParaneoplastische OsteopathieParaneoplastische OsteopathieStudies on ectopic ACTH-producing tumors.II. Clinical and biochemical features of 30 casesEctopic Adrenocorticotropin Syndrome Associated with Carcinoma of the ColonHYPERESTROGENISM BY TRANSPLANTABLE PULMONARY TUMORS OF MICEClinical and Laboratory Studies of Ectopic Humoral SyndromesPathology of ‘nonendocrine’ tumors associated with Cushing's syndromeEsophagusManagement of Esophageal Tumors 1 May 1965Volume 62, Issue 5Page: 1017-1022KeywordsAdrenocorticotropic hormoneAttentionBioassays and physiological analysisBlood plasmaEsophagusLungsMedical educationMetastatic tumorsPancreasThymus Issue Published: 1 May 1965 PDF DownloadLoading ...