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July 3, 2018International Journal of EndocrinologyOpen Access

Vitamin D had no significant effects on renin (312 mIU/L, 95% CI -279 to 902 ng/L; P=0.298) or aldosterone (-0.19 ng/L, 95% CI -5.09 to 4.70 ng/L; P=0.938) compared to placebo.

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Why the study?

Does vitamin D supplementation 4000 IU daily improve parameters of the RAAS in patients with advanced heart failure?

Population

165 patients with advanced heart failure

Comparison

Vitamin D supplementation 4000 IU daily for… vs Placebo

Design

RCT, randomized, placebo-controlled

Follow-up

3 years

Authors

AZArmin ZittermannHeart and Diabetes Center North Rhine-WestphaliaJEJana B. ErnstHeart and Diabetes Center North Rhine-WestphaliaSPSylvana ProkopHeart and Diabetes Center North Rhine-Westphalia

Discussion

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Member takes

Overview

Does not support vitamin D for RAAS modulation in advanced HF; confirms neutral effects on renin and aldosterone in this RCT.

Structured PICO

Does vitamin D supplementation 4000 IU daily improve parameters of the RAAS in patients with advanced heart failure?

P
Population
165 patients with advanced heart failure (almost all treated with beta-blockers, RAAS inhibitors, and diuretics)
I
Intervention
Vitamin D supplementation 4000 IU daily for three years
C
Comparator
Placebo
O
Outcome
Parameters of the RAAS (renin and aldosterone), circulating 1,25(OH)2D, plasma phosphate, and fibroblast growth factor (FGF)-23 at three yearssurrogate

In patients with advanced heart failure, 3 years of vitamin D supplementation (4000 IU daily) did not significantly influence RAAS parameters, though it increased renin in those with low baseline 25-hydroxyvitamin D.

Cite This Study

Zittermann et al. (2018) studied this question.

synapsesocial.com/papers/6a80d5cf1ece0ba82ce18bedhttps://doi.org/10.1155/2018/5015417
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of vitamin D on endothelial and ventricular function in chronic heart failure patients: A prospective, randomized, placebo-controlled trial2022 · 11 citations
  2. 2Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin—A Randomized Placebo‐Controlled Trial2016 · 44 citations
  3. 3The effect of vitamin D on renin–angiotensin system activation and blood pressure2016 · 126 citations
  4. 4Meta-analysis of vitamin D supplementation in the treatment of chronic heart failure2019 · 36 citations
  5. 5Vitamin D3 repletion versus placebo as adjunctive treatment of heart failure patient quality of life and hormonal indices: a randomized, double-blind, placebo-controlled trial2017 · 36 citations