Plasma renin and outcome in the community: data from PREVEND
Why the study?
Is plasma renin concentration associated with an increased risk of cardiovascular events in a community-based cohort not on antihypertensive medication?
Population
6,228 subjects enrolled in the Prevention of REnal and Vascular ENd-stage Disease study who were not using…
Design
Cohort
Follow-up
mean 10.5 years
Authors
Discussion
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Member takes
Implication
Plasma renin may aid CV risk stratification in untreated adults; extends observational data but leaves open causal trials.
Structured PICO
Is plasma renin concentration associated with an increased risk of cardiovascular events in a community-based cohort not on antihypertensive medication?
P
Population
6,228 subjects enrolled in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) study who were not using antihypertensive medication, mean age 47 (± 12) years, 49% male.
I
Intervention
Plasma renin concentration (observational exposure)
O
Outcome
Composite of fatal and non-fatal cardiovascular events at mean 10.5 years follow-upcomposite
Higher plasma renin concentration is independently associated with an increased risk of cardiovascular events in individuals not taking antihypertensive medications.
Cite This Study
Boer et al. (2012) studied this question.