September 26, 2007European Heart Journal
Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study
Why the study?
Does higher plasma renin predict the incidence of cardiovascular disease and mortality in a community-based population?
Population
3,408 individuals from the community, mean age 59, 53% women, including a hypertensive subset (n = 1,413).
Comparison
Higher plasma renin levels vs Lower plasma renin levels
Design
Cohort
Follow-up
mean 7.1 years
Authors
Discussion
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Member takes
Implication
Higher renin may flag short-term mortality risk in community cohorts; leaves open its value for CVD prediction or targeted trials.
Structured PICO
Does higher plasma renin predict the incidence of cardiovascular disease and mortality in a community-based population?
P
Population
3,408 individuals from the community, mean age 59, 53% women, including a hypertensive subset (n = 1,413).
I
Intervention
Higher plasma renin levels (evaluated as log-renin per SD increment)
C
Comparator
Lower plasma renin levels
O
Outcome
Incidence of cardiovascular disease (CVD) and mortalityhard clinical
Higher plasma renin is associated with greater short-term mortality but not with incident cardiovascular disease in a community-based cohort.
Cite This Study
Parikh et al. (2007) studied this question.