Why the study?
Rheumatoid arthritis is an independent risk factor for cardiovascular diseases, prompting a review of pathogenesis, treatment effects, associated complications, and risk assessment strategies.
Rheumatoid arthritis independently increases cardiovascular risk, necessitating strict cardiovascular risk management and careful selection of anti-rheumatic therapies to mitigate complications.
May warrant closer CV monitoring in RA; leaves open optimal DMARD selection for trials.
Rheumatoid arthritis (RA) is an independent risk factor for the development of a variety of cardiovascular diseases, with a 1.5-factor increase in risk. This literature review aims to provide a global overview of the pathogenesis, effects of anti-rheumatoid treatment on cardiovascular risk, a description of the cardiovascular complications associated with RA, and current opinion on cardiovascular risk assessment and management in patients with RA. Author conducted a literature search in PubMed, Scopus, Web of Science and Embase regarding RA and associated cardiovascular complications. The mechanism of increased risk of cardiovascular disease in patients with RA is complex. There are specific genetic factors associated with both diseases, and traditional cardiovascular risk factors may be more prevalent in patients with RA. Most anti-rheumatic drugs decrease cardiovascular risk, and general recommendations focus on reduction of disease activity and strict management of cardiovascular risk as per the general population.
No takes yet. Share an insight, caveat, or question.
Prashanth Rawla (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: