September 22, 1988New England Journal of Medicine
Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty Acids
Why the study?
Does eicosapentaenoic acid supplementation reduce early restenosis in male patients undergoing coronary angioplasty?
Population
82 male patients undergoing coronary angioplasty, at relatively high risk for restenosis.
Comparison
Eicosapentaenoic acid 3.2 g per day added to… vs Conventional antiplatelet regimen alone.
Design
RCT, randomized, unblinded clinical study, blinded angiographic analyses
Follow-up
6 months (angiogram at 3-4 months)
Authors
Discussion
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Implication
Supports EPA supplementation after angioplasty in men; extends randomized evidence for n-3 fatty acids in restenosis prevention.
Structured PICO
Does eicosapentaenoic acid supplementation reduce early restenosis in male patients undergoing coronary angioplasty?
P
Population
82 male patients undergoing coronary angioplasty (103 coronary lesions dilated), at relatively high risk for restenosis.
I
Intervention
Eicosapentaenoic acid 3.2 g per day added to conventional antiplatelet regimen (aspirin 325 mg and dipyridamole 225 mg per day), started 7 days before angioplasty and continued for 6 months.
C
Comparator
Conventional antiplatelet regimen alone (aspirin 325 mg and dipyridamole 225 mg per day).
O
Outcome
Incidence of early vessel restenosis determined on a second angiogram 3 to 4 months after angioplasty.surrogate
Supplementation with n-3 fatty acids (eicosapentaenoic acid) significantly reduces early angiographic restenosis after coronary angioplasty in men.
Limitations
- Male population only, unknown if applies to other populations
Cite This Study
Dehmer et al. (1988) studied this question.