High Sensitivity of Human Leukocyte Antigen–B*5701 as a Marker for Immunologically Confirmed Abacavir Hypersensitivity in White and Black Patients
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Discussion
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Implication
Case-control study shows 100% sensitivity of HLA-B*5701 for confirmed abacavir hypersensitivity in Black and White patients, suggesting consistent diagnostic utility across races.
Key Points
- To evaluate the sensitivity of HLA-B*5701 as a genetic marker for immunologically confirmed abacavir hypersensitivity reactions in White and Black patients.
- Retrospective chart review identified 130 White and 69 Black patients with clinically suspected abacavir hypersensitivity, categorized by skin patch testing as immunologically confirmed or unconfirmed.
- Genotyped HLA-B*5701 in case groups and racially matched control subjects who tolerated abacavir for ≥12 weeks to compute sensitivity, specificity, and odds ratios.
- Among patients with immunologically confirmed hypersensitivity, HLA-B*5701 sensitivity was 100% in White patients (42 of 42; OR 1945, 95% CI 110–34,352) and 100% in Black patients (5 of 5; OR 900, 95% CI 38–21,045).
- Among all clinically suspected cases, HLA-B*5701 sensitivity was 44% (57 of 130) in White patients and 14% (10 of 69) in Black patients, with specificities of 96% and 99% in respective control groups.
Cite This Study
Saag et al. (2008) studied this question.