Comparative sensitivity of cardiac troponin I and lactate dehydrogenase isoenzymes for diagnosing acute myocardial infarction
Why the study?
Is cardiac troponin I as sensitive as lactate dehydrogenase isoenzymes for the retrospective diagnosis of acute myocardial infarction?
Population
Patients with myocardial infarction admitted to the coronary care unit
Comparison
Cardiac troponin I (cTnI) measurement vs Lactate dehydrogenase (LD) isoenzymes measurement
Design
Cohort
Follow-up
4 days
Authors
Discussion
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Member takes
Implication
May support retrospective MI diagnosis on day 4; hypothesis-generating versus LD isoenzymes pending prospective validation.
Structured PICO
Is cardiac troponin I as sensitive as lactate dehydrogenase isoenzymes for the retrospective diagnosis of acute myocardial infarction?
P
Population
Patients with myocardial infarction admitted to the coronary care unit
I
Intervention
Cardiac troponin I (cTnI) measurement
C
Comparator
Lactate dehydrogenase (LD) isoenzymes measurement
O
Outcome
Relative sensitivity for the diagnosis of myocardial infarction over timesurrogate
Cardiac troponin I is highly sensitive for the retrospective diagnosis of acute myocardial infarction, persisting for several days, and should improve diagnostic accuracy over LD isoenzymes.
Cite This Study
Jaffe et al. (1996) studied this question.