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December 1, 2000Blood

Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: a single-institution study of 200 patients

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Authors

PSPetri SalvénUniversity of HelsinkiAOArto OrpanaHelsinki University HospitalLTLasse TeerenhoviRoswell Park Comprehensive Cancer Center

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Implication

Cohort study reveals reduced survival in non-Hodgkin lymphoma patients with co-elevated serum VEGF and bFGF, indicating strong independent prognostic utility.

Key Points

  • To evaluate whether combined serum levels of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) predict survival outcomes in non-Hodgkin lymphoma.
  • Single-institution cohort study analyzing pretreatment serum concentrations of VEGF and bFGF in N=200 patients with non-Hodgkin lymphoma.
  • Assessed survival correlations across median, tertile, and quartile cutoffs, followed by multivariate Cox modeling alongside International Prognostic Index (IPI) variables.
  • Patients with both S-VEGF and S-bFGF in the highest quartile had a 5-year survival rate of 21% versus 64% for patients with both markers in the lower three quartiles (P < .0001).
  • Multivariate analysis showed independent prognostic value for elevated S-VEGF (RR 1.83, P = .019) and S-bFGF (RR 2.02, P = .0049) alongside standard IPI factors.
  • Concurrent elevation of both markers in the highest quartile conferred nearly a threefold increase in mortality risk (RR 2.90, 95% CI 1.56–5.40, P = .0008), outperforming any single IPI component.

Cite This Study

Salvén et al. (2000) studied this question.

synapsesocial.com/papers/6a80eebfada1eccddc337b24https://doi.org/10.1182/blood.v96.12.3712
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Also Consider

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  1. 1The Biology of Vascular Endothelial Growth Factor1997 · 4,371 citations
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  3. 3Constitutive and selective expression of basic fibroblast growth factor in human leukaemia cell lines1995 · 18 citations
  4. 4Vascular endothelial growth factor serum concentrations in ovarian cancer1998 · 115 citations
  5. 5Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction1995 · 462 citations