Key result
VEGF-936C/T and bFGF-921C/G gene polymorphisms showed borderline significant associations with advanced clinical staging (P=0.082) and higher International Prognostic Index scores in NHL patients.
Why the study?
Are VEGF -936C/T and bFGF -921C/G gene polymorphisms associated with disease progression in patients with Non-Hodgkin Lymphoma?
Observational (n=50)
Are VEGF -936C/T and bFGF -921C/G gene polymorphisms associated with disease progression in patients with Non-Hodgkin Lymphoma?
VEGF-936C/T and bFGF-921C/G gene polymorphisms may be associated with disease progression and aggressive histological subtypes in Non-Hodgkin Lymphoma, though findings were of borderline statistical significance.
Lymphoma growth and progression may be enhanced by angiogenesis. Both vascular endothelialgrowth factor (VEGF) and basic fibroblast growth factor (bFGF) play an important role in this process. Thepresent study aimed to investigate the association of VEGF -936C/T and bFGF -921C/G gene polymorphismswith the clinicopathological characteristics of the studied patients and progression of NHL disease.Patients and methods: Clinico-hematological profiles were done for 50 NHL patients. The genotypes andallelic frequencies of VEGF and bFGF polymorphisms were detected using Polymerase Chain ReactionRestriction Fragment Length Polymorphism (PCR-RFLP). PCR products after adding restriction endonucleasewere analyzed using QIAxcel advanced (automated) instrument.Results: there was a trend of significance of VEGF 936-T allele among NHL patients with advanced clinicalstaging compared to patients with early stages withP value 0.082. As regards the progression of the diseasedetermined by international prognostic index (IPI), it was noticed that there was a borderline significancebetween VEGF CT genotype and IPI score among patients with intermediate high/high IPI compared topatients with low/intermediate low IPI withP value 0.074. The bFGF 921-G variant was associated frequentlywith aggressive histological subtype of NHL and showed a borderline significance with NHL patientspresented with intermediate high/high IPI score and BM infiltration withP value 0.098 and 0.054 respectively.Conclusion: our results demonstrated that VEGF-936C/T and bFGF-921C/G gene polymorphisms maypotentially affect the progression of NHL. Further larger scale studies are needed.
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A 2018 study conducted an observational in Non-Hodgkin Lymphoma (n=50). VEGF -936C/T and bFGF -921C/G gene polymorphisms was evaluated on Association with clinicopathological characteristics and progression of NHL disease. VEGF-936C/T and bFGF-921C/G gene polymorphisms showed borderline significant associations with advanced clinical staging (P=0.082) and higher International Prognostic Index scores in NHL patients.
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