April 29, 2013The Journal of General PhysiologyOpen Access

TMEM16F (Anoctamin 6), an anion channel of delayed Ca2+ activation

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Population

HEK293 cells expressing mouse TMEM16F

Design

Preclinical

Authors

SGSøren GrubbUniversity of Copenhagen KPKristian A. PoulsenUniversity of Copenhagen CJChristian Ammitzbøll JuulTechnical University of Denmark

Discussion

Member takes

Implication

Animal study of TMEM16F; extends Ca2+-activated channel classification but leaves open human cardiovascular relevance.

Structured PICO

Population

HEK293 cells expressing mouse TMEM16F

Intervention

Heterologous expression of mouse TMEM16F and its mutants (R592E, K616E, R636E)

Outcome

Electrophysiological properties including plasma membrane localization, ICl,Ca activation, Na+ current, EC50, and anion selectivity sequencesurrogate

This preclinical study demonstrates that TMEM16F functions as a delayed Ca2+-activated anion channel with distinct electrophysiological properties compared to TMEM16A.

Cite This Study

Grubb et al. (2013) studied this question.

synapsesocial.com/papers/6a80fef61325e503433c740e https://doi.org/10.1085/jgp.201210861

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