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In vitro study demonstrates that isoproterenol increases ciliary beating in rabbit tracheal cells, indicating beta-adrenergic regulation of airway clearance.
We investigated the effect of isoproterenol on ciliary activity using a mucus-free preparation of cultured ciliated cells of the rabbit trachea. The frequency of ciliary beating was monitored by dynamic laser-scattering spectroscopy. The results demonstrated that isoproterenol directly stimulates the activity of ciliated cells of the respiratory epithelium and that this effect is beta-adrenergic specific inasmuch as the observed stimulation can be blocked by propranolol.
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Verdugo et al. (1980) studied this question.
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