What question did this study set out to answer?

To systematically examine the bidirectional biological mechanisms linking circadian rhythm dysregulation with the onset and progression of insulin resistance.

April 3, 2025Biological Rhythm Research

Biological connection of circadian rhythm and insulin resistance: a review

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Authors

AKAnil KumarDr. Yashwant Singh Parmar University of Horticulture and Forestry SDSushma DeviArunai Engineering College

Discussion

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Implication

Review uncovers bidirectional links between circadian rhythm disruptions and insulin resistance in biological systems, highlighting molecular pathways driving type 2 diabetes.

Key Points

To systematically examine the bidirectional biological mechanisms linking circadian rhythm dysregulation with the onset and progression of insulin resistance.
Reviewed published molecular and physiological studies investigating the interplay between circadian clock machinery and insulin signaling pathways.
Evaluated the roles of core clock genes (CLOCK, BMAL1, PER, CRY) and hormonal variations alongside melatonin receptor (MTNR1B) expression.
Circadian disruption alters core clock gene oscillations and hormonal rhythms, leading to impaired insulin sensitivity and compromised glucose regulation.
Insulin resistance reciprocally disturbs circadian rhythm function by modifying the expression of melatonin receptors and clock-controlled genes, exacerbating metabolic dysfunction.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/6a81293fec86ba91653bf73c https://doi.org/10.1080/09291016.2025.2480148

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April 3, 2025Biological Rhythm Research

Biological connection of circadian rhythm and insulin resistance: a review

View Full Paper

Ask AI

Bookmark

Authors

AKAnil KumarDr. Yashwant Singh Parmar University of Horticulture and Forestry SDSushma DeviArunai Engineering College

Discussion

Member takes

Implication

Review uncovers bidirectional links between circadian rhythm disruptions and insulin resistance in biological systems, highlighting molecular pathways driving type 2 diabetes.

Key Points

To systematically examine the bidirectional biological mechanisms linking circadian rhythm dysregulation with the onset and progression of insulin resistance.
Reviewed published molecular and physiological studies investigating the interplay between circadian clock machinery and insulin signaling pathways.
Evaluated the roles of core clock genes (CLOCK, BMAL1, PER, CRY) and hormonal variations alongside melatonin receptor (MTNR1B) expression.
Circadian disruption alters core clock gene oscillations and hormonal rhythms, leading to impaired insulin sensitivity and compromised glucose regulation.
Insulin resistance reciprocally disturbs circadian rhythm function by modifying the expression of melatonin receptors and clock-controlled genes, exacerbating metabolic dysfunction.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/6a81293fec86ba91653bf73c https://doi.org/10.1080/09291016.2025.2480148

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