Why the study?
Blood-brain barrier disruption, modulated by APOE4 mutation, is implicated in cognitive decline, but whether permeability differs by cognitive functioning and APOE4 status in elderly subjects without dementia remained to be determined.
Does hippocampal blood-brain barrier permeability differ according to APOE4 status and predict cognitive functioning in elderly individuals without dementia?
Does hippocampal blood-brain barrier permeability differ according to APOE4 status and predict cognitive functioning in elderly individuals without dementia?
Hippocampal blood-brain barrier permeability measured by MRI is associated with APOE4 mutation status and may serve as an imaging biomarker for cognitive functioning in elderly individuals without dementia.
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Should not yet alter practice in APOE4 carriers; leaves open hippocampal BBB permeability as a cognitive biomarker.
Moon et al. (2020) studied this question.
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