Why the study?
Does nerve growth factor alter the lipid composition of PC12 pheochromocytoma cells?
Population
PC12 pheochromocytoma cells
Comparison
Nerve growth factor (NGF) vs Absence of nerve growth factor (NGF)
Design
Preclinical
Authors
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NGF doubles ganglioside content in PC12 cells without changing total lipids; leaves open relevance to primary neurons or differentiation.
Does nerve growth factor alter the lipid composition of PC12 pheochromocytoma cells?
PC12 pheochromocytoma cells contain globoside as a major neutral glycolipid, and NGF treatment increases total ganglioside concentration without altering the relative proportions of individual gangliosides.
Ariga et al. (1988) studied this question.
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