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January 19, 2023Research in Pharmaceutical SciencesOpen Access

Protective effects of protocatechuic acid against doxorubicin- and arsenic trioxide-induced toxicity in cardiomyocytes

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Why the study?

Certain chemotherapeutic agents increase cardiotoxicity risk, and this study aimed to evaluate whether protocatechuic acid protects cardiomyocytes against toxicity induced by doxorubicin and arsenic trioxide.

Does protocatechuic acid prevent doxorubicin- and arsenic trioxide-induced toxicity in H9C2 cardiomyocytes?

Population

H9C2 cardiomyocytes

Comparison

PCA pretreatment (1-100 μM) before DOX (1 μM) or ATO (35 μM) exposure vs untreated controls

Design

In vitro experimental study

Authors

SFShafiee FatemehLSLeila SafaeianFGFatemeh Gorbani

Discussion

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Overview

May support preclinical testing of PCA for anthracycline/arsenic cardiotoxicity; leaves open translation to in vivo or clinical use.

Structured PICO

Does protocatechuic acid prevent doxorubicin- and arsenic trioxide-induced toxicity in H9C2 cardiomyocytes?

P
Population
H9C2 cells (cardiomyocytes)
I
Intervention
Protocatechuic acid (PCA) (1-100 μM) pretreatment for 24 h
C
Comparator
Exposure to doxorubicin (1 μM) or arsenic trioxide (35 μM) without PCA pretreatment
O
Outcome
Cell viability and cytotoxicity (MTT and LDH tests)surrogate

Protocatechuic acid demonstrates cardioprotective effects against doxorubicin- and arsenic trioxide-induced toxicity in vitro by reducing oxidative stress and TLR4 expression.

Cite This Study

Fatemeh et al. (2023) studied this question.

synapsesocial.com/papers/6a8138039fceb4fbd5e3ddbbhttps://doi.org/10.4103/1735-5362.367794
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Also Consider

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  1. 1Protocatechuic acid exerts a cardioprotective effect in type 1 diabetic rats2014 · 73 citations
  2. 2Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats2012 · 44 citations
  3. 3Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway2021 · 35 citations
  4. 4In vitro antioxidant effects of different extracts obtained from the leaves and seeds of Allium ampeloprasum subsp. persicum2019 · 25 citations
  5. 5The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury2014 · 49 citations