Why the study?
Does quantitative CRP measurement accurately diagnose acute appendicitis in patients with suspected appendicitis?
Does quantitative CRP measurement accurately diagnose acute appendicitis in patients with suspected appendicitis?
Quantitative CRP measurement is a useful adjunct in diagnosing acute appendicitis, with elevated levels correlating with histopathologically confirmed appendicitis.
CRP may aid suspected appendicitis diagnosis; leaves open its standalone accuracy in observational data.
BACKGROUNDAppendectomy is one of the commonest procedures in surgery.In spite of various investigations used to improve the accuracy of diagnosis, the rate of normal appendices removed is still about 15-30%.Many studies have investigated the role of C-Reactive Protein (CRP) in acute appendicitis, but with conflicting results. METHODSIn a prospective, double-blind study, blood for the measurement of serum C-reactive protein was collected preoperatively from patients before going to the operating theatre for appendectomy.The histopathology was grouped into positive (acute appendicitis) and negative (normal appendix) and this was correlated with CRP values. RESULTSCRP was normal in 14 out of 20 negative explorations (normal appendix on histopathology).The specificity and sensitivity of serum CRP was 58% and 91% respectively.The predictive value of a positive (raised CRP) and negative (normal CRP) test is 88% and 48% respectively. CONCLUSIONWe conclude that quantitative measurement of CRP value is helpful in the diagnosis of acute appendicitis.Routine CRP measurement helps surgeon to make the diagnosis of appendicitis.
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Ramula et al. (2016) studied this question.
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