What question did this study set out to answer?

To synthesize mechanistic insights into how early and advanced glycation promotes diabetic vascular injury and evaluate therapeutic approaches targeting advanced glycation end product pathways.

March 30, 2017Current Vascular Pharmacology

A Glycation Angle to Look into the Diabetic Vasculopathy: Cause and Cure

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Authors

SASaheem AhmadUniversity of Ha'il ZSZeba SiddiquiEra's Lucknow Medical College and Hospital SRShahnawaz RehmanIntegral University

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Implication

Review reveals that advanced glycation end products drive vascular damage in diabetes, suggesting that inhibiting glycation pathways delays diabetic vasculopathy.

Key Points

To synthesize mechanistic insights into how early and advanced glycation promotes diabetic vascular injury and evaluate therapeutic approaches targeting advanced glycation end product pathways.
Literature review of preclinical studies examining advanced glycation end product (AGE) generation from reducing sugars and biomolecules.
Analysis of pathological pathways involving receptor for advanced glycation end products (RAGE) signaling, tissue cross-linking, and vascular stiffness.
Evaluation of experimental interventions aimed at inhibiting AGE formation, promoting AGE degradation, or interrupting AGE-RAGE receptor binding.
Accumulation of AGEs directly alters nucleic acids, proteins, and lipids, causing biomolecular cross-linking that drives progressive vascular stiffness and remodeling.
AGE interaction with RAGE activates downstream intracellular signaling cascades that exacerbate oxidative stress and stimulate pro-sclerotic and pro-inflammatory cytokines.
Pharmacological inhibition of glycation mechanisms and disruption of AGE-RAGE interactions significantly delay the onset and progression of microvascular and macrovascular complications.

Cite This Study

Ahmad et al. (2017) studied this question.

synapsesocial.com/papers/6a8139bdadfa6baaaee1bf0c https://doi.org/10.2174/1570161115666170327162639

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Implication

Review reveals that advanced glycation end products drive vascular damage in diabetes, suggesting that inhibiting glycation pathways delays diabetic vasculopathy.

A Glycation Angle to Look into the Diabetic Vasculopathy: Cause and Cure

Discussion

Member takes

Implication

Key Points

Cite This Study

A Glycation Angle to Look into the Diabetic Vasculopathy: Cause and Cure

Discussion

Member takes

Implication

Key Points

Cite This Study

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