What question did this study set out to answer?

Synthesize the chemical formation, pathobiological signaling mechanisms, diagnostic detection methods, and therapeutic strategies associated with advanced glycation end products across multiple organ systems in diabetes.

August 16, 2026Diabetology & Metabolic SyndromeOpen Access

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

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Authors

XCXinyu CuiStomatology Hospital YLYuanyuan LiuQilu University of Technology XYXuechao YuQingdao University

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Implication

Narrative review reveals multi-organ pathogenic mechanisms of advanced glycation end products in diabetes, highlighting novel therapeutic targets and natural inhibitors.

Key Points

Synthesize the chemical formation, pathobiological signaling mechanisms, diagnostic detection methods, and therapeutic strategies associated with advanced glycation end products across multiple organ systems in diabetes.
Reviewed mechanisms of advanced glycation end product (AGE) synthesis via dietary intake and hyperglycemic Maillard reactions.
Evaluated pathological signaling cascades involving NF-κB, NADPH oxidase, p38, and JNK across cardiovascular, musculoskeletal, and peripheral nervous systems.
Assessed conventional and novel AGE detection methods alongside emerging interventions, including natural products (resveratrol, chrysin) and competitive inhibitors.
AGEs drive multisystem diabetic complications by tissue cross-linking and activating receptor-mediated cascades that increase reactive oxygen species and inflammatory factors while disrupting osteoclast-osteoblast homeostasis.
Natural polyphenols such as resveratrol and chrysin, along with competitive inhibitors, reduce AGE accumulation and disrupt AGE–RAGE interactions to mitigate organ damage.

Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a817a91f2fb91fc834ae7f9 https://doi.org/10.1186/s13098-026-02280-3

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Implication

Narrative review reveals multi-organ pathogenic mechanisms of advanced glycation end products in diabetes, highlighting novel therapeutic targets and natural inhibitors.

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

Discussion

Member takes

Implication

Key Points

Cite This Study

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

Discussion

Member takes

Implication

Key Points

Cite This Study

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