July 11, 2006AJP Endocrinology and Metabolism

The PPARγ agonist pioglitazone modifies the vascular sodium-angiotensin II relationship in insulin-resistant rats

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Population

8-week-old obese Zucker rats

Comparison

Pioglitazone administered for 4 weeks, with… vs Vehicle administered for 4 weeks, with animals…

Design

Preclinical

Follow-up

4 weeks

Authors

AZAnne ZanchiUniversity Hospital of Lausanne CPChristine PerregauxUniversity Hospital of Lausanne MMMarc MaillardUniversity of Lausanne

Discussion

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Implication

Does not support clinical use in hypertension; leaves open translation of AT1 effects from insulin-resistant rat models.

Structured PICO

Population

8-week-old obese Zucker rats

Intervention

Pioglitazone administered for 4 weeks, with animals fed a normal-sodium (NS) or high-sodium (HS) diet

Comparator

Vehicle administered for 4 weeks, with animals fed a normal-sodium (NS) or high-sodium (HS) diet

Outcome

Systemic and renal hemodynamic responses to ANG II, renal ANG II binding, and expression of ANG II type 1 (AT1) receptorssurrogate

Pioglitazone modifies the physiological relationship between sodium chloride and the response to ANG II in insulin-resistant rats, associated with decreased AT1 receptor expression.

Cite This Study

Zanchi et al. (2006) studied this question.

synapsesocial.com/papers/6a813a2544e915b2ef64613e https://doi.org/10.1152/ajpendo.00171.2006

View Full Paper

Ask AI

Bookmark

The PPARγ agonist pioglitazone modifies the vascular sodium-angiotensin II relationship in insulin-resistant rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The PPARγ agonist pioglitazone modifies the vascular sodium-angiotensin II relationship in insulin-resistant rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider