Pioglitazone attenuated the development of hypertension, significantly lowering systolic blood pressure in Dahl salt-sensitive rats (P<0.05) and one-kidney, one-clip Sprague-Dawley rats (P<0.0001).
Does pioglitazone reduce blood pressure and inhibit renal arteriolar smooth muscle growth in hypertensive rat models?
Pioglitazone attenuates hypertension in rat models, an effect that may be partly mediated by its ability to inhibit vascular smooth muscle growth.
p-value: p=<0.05
Hypertension is frequently associated with insulin resistance. We evaluated the effects of pioglitazone, an agent that increases insulin sensitivity, on the development of hypertension in the Dahl salt-sensitive (Dahl-S) rat and in the one-kidney, one-clip Sprague-Dawley rat. We also evaluated the effects of pioglitazone on growth of cultured preglomerular renal arteriolar smooth muscle cells. In Dahl-S rats fed a 3% NaCl diet, tail systolic blood pressures and direct arterial pressures were lower (P < 0.05) in pioglitazone-treated (20 mg/kg daily by gavage for 3 wk) than in control rats (n = 10 rats/group). In one-kidney, one-clip Sprague-Dawley rats, systolic blood pressures were also lower in pioglitazone-treated animals (P < 0.0001). In vitro, proliferation of arteriolar smooth muscle cells was stimulated (P < 0.01) by insulin, epidermal growth factor (EGF), and fetal calf serum (FCS); pioglitazone (5 microM) reversibly inhibited (P < 0.01) insulin-, EGF-, and FCS-induced proliferation. Pioglitazone (0.01-100 microM) also inhibited insulin- (1 mU/ml), EGF- (100 ng/ml), and 5% FCS-induced 3Hthymidine incorporation in a concentration-dependent manner (P < 0.01). Thus pioglitazone attenuated the development of hypertension in the Dahl-S rat and the one-kidney, one-clip rat. The ability of pioglitazone to inhibit growth of vascular smooth muscle may contribute to its hypotensive effect.
Dubey et al. (Fri,) conducted a other in Hypertension. Pioglitazone vs. Control was evaluated on Systolic blood pressure and direct arterial pressure (p=<0.05). Pioglitazone attenuated the development of hypertension, significantly lowering systolic blood pressure in Dahl salt-sensitive rats (P<0.05) and one-kidney, one-clip Sprague-Dawley rats (P<0.0001).