Key result
Pioglitazone attenuated the development of hypertension, significantly lowering systolic blood pressure in Dahl salt-sensitive rats (P<0.05) and one-kidney, one-clip Sprague-Dawley rats (P<0.0001).
Why the study?
Does pioglitazone reduce blood pressure and inhibit renal arteriolar smooth muscle growth in hypertensive rat models?
Population
Dahl salt-sensitive rats fed a 3% NaCl diet, one-kidney, one-clip Sprague-Dawley rats, and cultured…
Comparison
Pioglitazone vs Control rats and untreated cells
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for insulin sensitization in salt-sensitive hypertension; human trials needed before clinical consideration.
Does pioglitazone reduce blood pressure and inhibit renal arteriolar smooth muscle growth in hypertensive rat models?
p-value: p=<0.05
Pioglitazone attenuates hypertension in rat models, an effect that may be partly mediated by its ability to inhibit vascular smooth muscle growth.
Dubey et al. (1993) studied Hypertension. Pioglitazone vs. Control was evaluated on Systolic blood pressure and direct arterial pressure (p=<0.05). Pioglitazone attenuated the development of hypertension, significantly lowering systolic blood pressure in Dahl salt-sensitive rats (P<0.05) and one-kidney, one-clip Sprague-Dawley rats (P<0.0001).
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