Why the study?
Does pioglitazone reduce left ventricular hypertrophy and fibrosis in a rat model of salt-sensitive hypertension?
Population
Dahl salt-sensitive rats at 16 weeks of age after being fed a high-salt (8%) diet for 10 weeks
Comparison
Pioglitazone (10 mg/kg/day) vs Candesartan (4 mg/kg/day) or low-salt (0.3%) diet
Design
Preclinical
Follow-up
10 weeks
Authors
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Should not yet change practice; hypothesis-generating for pioglitazone in salt-sensitive LV remodeling.
Does pioglitazone reduce left ventricular hypertrophy and fibrosis in a rat model of salt-sensitive hypertension?
Pioglitazone attenuates left ventricular hypertrophy and fibrosis in a rat model of salt-sensitive hypertension, suggesting potential cardiovascular protective effects beyond glycemic control.
Nakamoto et al. (2008) studied this question.
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