November 1, 1998AJP Heart and Circulatory Physiology
Mitochondrial ATP-sensitive K+channels modulate cardiac mitochondrial function
Population
Isolated mitochondria from rat hearts
Comparison
K+ channel openers vs Removal of extramitochondrial K+ or application…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for mitochondrial KATP effects in rat cardiac tissue; requires in vivo and clinical validation before any practice implications.
Structured PICO
P
Population
Isolated mitochondria from rat hearts
I
Intervention
K+ channel openers (pinacidil 100 microM, cromakalim 25 microM, and levcromakalim 20 microM)
C
Comparator
Removal of extramitochondrial K+ or application of a KATP channel blocker
O
Outcome
Effect on mitochondrial membrane potential, respiration, ATP generation, Ca2+ transport, and matrix volumesurrogate
In isolated rat cardiac mitochondria, KATP channel openers depolarize the membrane, accelerate respiration, slow ATP production, and release accumulated Ca2+, providing direct evidence for their role in regulating vital mitochondrial functions.
Cite This Study
Holmuhamedov et al. (1998) studied this question.