Why the study?
The mechanisms underlying the antithrombotic actions of aspirin have not been fully elucidated.
Does low-dose aspirin affect platelet reactivity, antithrombin activity, and blood cell parameters in patients with ischemic atherothrombotic diseases?
Population
51 patients with ischemic atherothrombotic diseases (17 per group after matching)
Comparison
No aspirin vs 25-50 mg/d aspirin vs 75-100 mg/d aspirin over 1 month
Design
1:1:1 propensity score-matched re-analysis
Authors
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May support broader antithrombotic effects of low-dose aspirin; hypothesis-generating and should not change practice without randomized confirmation.
Does low-dose aspirin affect platelet reactivity, antithrombin activity, and blood cell parameters in patients with ischemic atherothrombotic diseases?
Low-dose aspirin exerts antithrombotic effects not only through antiplatelet function but also by enhancing antithrombin activity and suppressing monocytes in vivo.
Li et al. (2020) studied this question.