Why the study?
Does dynamic contrast-enhanced MR imaging correlate with histologic markers of inflammation and clinical cardiovascular risk factors in patients undergoing carotid endarterectomy?
Population
30 patients (29 men, 1 woman; mean age 67.7 +/- 10.7 years) scheduled to undergo carotid endarterectomy.
Design
Cohort, Blinded MR measurements
Authors
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Ktrans may indicate carotid plaque inflammation noninvasively; observational correlations leave open its role in clinical risk assessment.
Does dynamic contrast-enhanced MR imaging correlate with histologic markers of inflammation and clinical cardiovascular risk factors in patients undergoing carotid endarterectomy?
Dynamic contrast-enhanced MRI parameters, specifically Ktrans, correlate strongly with histologic markers of plaque inflammation and clinical risk factors, suggesting its utility as a noninvasive marker of carotid plaque vulnerability.
Kerwin et al. (2006) studied this question.
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