Key result
Dynamic contrast-enhanced MRI estimates of fractional blood volume in carotid plaques were highly correlated with histological measurements of fractional vascular area (correlation coefficient 0.80, P<0.001).
Why the study?
Does dynamic contrast-enhanced MRI accurately measure neovasculature volume in carotid atherosclerotic plaques compared to histology in patients scheduled for carotid endarterectomy?
Population
20 consecutive patients scheduled for carotid endarterectomy
Comparison
Dynamic contrast-enhanced MRI with gadolinium… vs Histological measurements of matched sections…
Design
Cross-sectional
Authors
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Supports noninvasive carotid plaque neovascularization assessment by DCE-MRI; leaves open its role in vulnerability stratification pending prospective studies.
Observational (n=20)
Does dynamic contrast-enhanced MRI accurately measure neovasculature volume in carotid atherosclerotic plaques compared to histology in patients scheduled for carotid endarterectomy?
Effect estimate: correlation coefficient 0.80
p-value: p=<0.001
Dynamic contrast-enhanced MRI can noninvasively and accurately estimate the extent of neovasculature within carotid atherosclerotic plaques, providing a potential tool for assessing plaque vulnerability.
Kerwin et al. (2003) conducted an observational in Carotid atherosclerotic plaque (n=20). Dynamic contrast-enhanced MRI vs. Histological measurements was evaluated on Correlation between MRI-estimated fractional blood volume and histological fractional vascular area (correlation coefficient 0.80, p=<0.001). Dynamic contrast-enhanced MRI estimates of fractional blood volume in carotid plaques were highly correlated with histological measurements of fractional vascular area (correlation coefficient 0.80, P<0.001).
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