Population pharmacodynamics of cilostazol in healthy Korean subjects

Figures

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  Figure 1. Observed cilostazol concentrations and closure times; the solid line represents a smoothed line of concentrations and the dashed line a smoothed line of closure times.

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  Figure 2. Goodness-of-fit plots for the final PD model; open circles are observations, red lines smoothed lines, and black lines the line of identity (upper panels) and the zero residual line (lower panels).

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  Figure 3. Visual predictive check for the final PD model; circles represent observed closure times, dashed lines represent 5th, median, and 95th percentiles of predictions, solid lines represent 5th, median, and 95th percentiles of observations, and shaded areas represent 95% confidence intervals of 5th, median, and 95th percentiles of predictions. Time ranges are 0~192 hr in upper panel and 168~192 hr in lower panel, respectively.