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February 8, 2008Arteriosclerosis Thrombosis and Vascular Biology

Angiopoietin-Related Growth Factor Enhances Blood Flow Via Activation of the ERK1/2-eNOS-NO Pathway in a Mouse Hind-Limb Ischemia Model

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Why the study?

Does angiopoietin-related growth factor (AGF) enhance blood flow and angiogenesis in a mouse hind-limb ischemia model?

Population

Mouse hind-limb ischemia model and human umbilical venous endothelial cells

Comparison

Intramuscular injection of adenovirus harboring… vs Mice receiving NOS inhibitor L-NAME, eNOS…

Design

Preclinical

Authors

TUTakashi UranoKawasaki Medical SchoolYIYasuhiro ItoHamamatsu University HospitalMAMasaki AkaoKobe University

Discussion

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Implication

AGF merits further preclinical testing for ischemic disease; leaves open translation to human peripheral artery disease therapy.

Structured PICO

Does angiopoietin-related growth factor (AGF) enhance blood flow and angiogenesis in a mouse hind-limb ischemia model?

P
Population
Mouse hind-limb ischemia model (including wild-type and eNOS knockout mice) and human umbilical venous endothelial cells (HUVECs)
I
Intervention
Intramuscular injection of adenovirus harboring angiopoietin-related growth factor (AGF) (in vivo) and exposure to AGF (in vitro)
C
Comparator
Mice receiving NOS inhibitor L-NAME, eNOS knockout mice, and implied untreated controls
O
Outcome
Blood flow enhancement, angiogenesis, arteriogenesis, and limb amputation ratesurrogate

AGF enhances blood flow and promotes angiogenesis in ischemic tissue via the ERK1/2-eNOS-NO signaling pathway, highlighting its potential as a therapeutic target for ischemic vascular diseases.

Cite This Study

Urano et al. (2008) studied this question.

synapsesocial.com/papers/6a814a3e176d2ce031661326https://doi.org/10.1161/atvbaha.107.149674
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium1996 · 117 citations
  2. 2Angiopoietin-related growth factor (AGF) promotes angiogenesis2004 · 123 citations
  3. 3Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.1998 · 1,205 citations
  4. 4Molecular Cloning, Expression, and Characterization of Angiopoietin-related Protein1999 · 215 citations
  5. 5Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation2000 · 405 citations