Why the study?
Does the coadministration of Ang1 and VEGF enhance collateral vascularization compared to either factor alone in preclinical models?
Population
Primary cultured porcine coronary artery endothelial cells and a rabbit ischemic hindlimb model
Comparison
Combination of Angiopoietin-1 and Vascular… vs Ang1 alone or VEGF alone
Design
Preclinical
Authors
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Supports synergistic angiogenesis with combined Ang1-VEGF in animal ischemia models; leaves open clinical translation.
Does the coadministration of Ang1 and VEGF enhance collateral vascularization compared to either factor alone in preclinical models?
Coadministration of Ang1 and VEGF synergistically enhances collateral vascularization and blood flow in preclinical models of ischemia.
Chae et al. (2000) studied this question.
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