Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction
Why the study?
Does baseline galectin-3 predict left ventricular remodeling in survivors of acute myocardial infarction with LV dysfunction?
Population
100 patients admitted with acute myocardial infarction and LV dysfunction (mean age 58.9±12.0 years, 77% men)
Design
Cohort
Follow-up
24 weeks
Authors
Discussion
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Member takes
Implication
Galectin-3 should not yet guide post-MI remodeling risk assessment; leaves open selective association in preserved LVEF.
Structured PICO
Does baseline galectin-3 predict left ventricular remodeling in survivors of acute myocardial infarction with LV dysfunction?
P
Population
100 patients admitted with acute myocardial infarction and LV dysfunction (mean age 58.9±12.0 years, 77% men)
I
Intervention
Measurement of circulating galectin-3 and extracellular matrix biomarkers
O
Outcome
Left ventricular remodeling defined as change in LV end-systolic volume index at 24 weeks measured by cardiac MRIsurrogate
Galectin-3 levels increase over time after acute myocardial infarction but do not definitively predict left ventricular remodeling across all patients, though a correlation exists in those with more preserved ejection fraction.
Cite This Study
Weir et al. (2013) studied this question.