Key result
Elevated Gal-3 levels are associated with acute and prior MI versus controls.
Why the study?
The relationship between circulating Galectin-3 levels and acute versus old myocardial infarction assessed by cardiac magnetic resonance imaging was unclear.
Observational (n=112)
Gal-3 should not guide acute MI assessment; leaves open its role in chronic remodeling.
OBJECTIVES: Galectin-3 (Gal-3) is involved in cardiac inflammation and fibrosis, and is in use as a biomarker that indicates increased risk in heart failure. This study examined the relationship between Gal-3 levels and acute and old myocardial infarction (MI) in patients assessed by cardiac magnetic resonance (CMR) imaging. METHODS: Group 1 consisted of 38 patients with ST-elevation MI and single-vessel disease treated with primary percutaneous coronary intervention (PCI). Group 2 consisted of 52 patients with prior complicated MI. Twenty-two controls were included. CMR was performed in group 1 at 2 days, 1 week, 2 months and 1 year following PCI and in group 2 at >4 years after MI. RESULTS: Median Gal-3 was elevated in patients compared with controls, group 1: 11.93 ng/ml (IQR 6.34-17.52, p = 0.03), group 2: 12.96 (IQR 6.33-19.29, p = 0.03) and controls: 10.16 (IQR 5.59-14.73). Gal-3 levels did not change during acute MI, and there was no relationship between Gal-3 and infarct size, troponin-T, high-sensitivity C-reactive protein, left-ventricular (LV) volumes or LV ejection fraction (LVEF) in group 1. In group 2, Gal-3 correlated modestly with MI size (r = 0.28, p < 0.05), LV end-diastolic volume index (r = 0.40, p < 0.01), LV end-systolic volume index (r = 0.43, p < 0.01) and LVEF (r = -0.39, p < 0.01). CONCLUSION: There was no relationship between Gal-3 levels and acute ischemic myocardial injury. A significant, modest relationship between Gal-3 levels, MI size and LV remodeling was only found in patients with old MI.
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Singsaas et al. (2016) conducted an observational in Ischemic Heart Disease / Myocardial Infarction (n=112). Galectin-3 (Gal-3) levels vs. Healthy controls was evaluated on Median Gal-3 levels (ng/ml) (p=0.03). Median Gal-3 levels were elevated in acute (11.93 ng/ml) and old MI (12.96 ng/ml) versus controls (10.16 ng/ml; p=0.03), but did not change during acute MI and only correlated with MI size in old MI.
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