Population
Male Hanover Wistar rats
Design
Preclinical
Follow-up
0.5 to 72 hours
Authors
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Supports troponin/H-FABP monitoring in rat cardiotoxicity models; leaves open human translation and clinical adoption.
Serum cardiac troponins are sensitive and specific early markers for detecting acute cardiomyocyte injury prior to necrosis in rat toxicity studies.
Clements et al. (2010) studied this question.
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