What question did this study set out to answer?

To measure inspiratory flow rates generated through the HandiHaler across different stages of chronic obstructive pulmonary disease (COPD) and determine in vitro particle delivery at low flow rates.

September 1, 2001Journal of Aerosol Medicine

Effective Delivery of Particles with the HandiHaler® Dry Powder Inhalation System over a Range of Chronic Obstructive Pulmonary Disease Severity

View Full Paper

Ask AI

Bookmark

Authors

SCSanford ChodoshBoston University JFJon Flanders SKSteven KestenSalish Kootenai College

Discussion

Member takes

Implication

Physiologic study demonstrates sufficient inspiratory flow with HandiHaler in chronic obstructive pulmonary disease, suggesting reliable drug delivery across all disease severities.

Key Points

To measure inspiratory flow rates generated through the HandiHaler across different stages of chronic obstructive pulmonary disease (COPD) and determine in vitro particle delivery at low flow rates.
Assessed in vitro fine particle dose delivery at inspiratory flow rates down to 20 L/min using an Andersen Cascade Impactor.
Measured in vivo peak inspiratory flow rates using a pneumotach coupler in N=26 men with stable COPD (age 66.9 ± 10.9 years; FEV1 = 1.02 ± 0.45 L) categorized by spirometric severity into mild (FEV1 46–65%, n=8), moderate (FEV1 28–45%, n=10), and severe (FEV1 ≤27%, n=8).
In vitro testing demonstrated effective fine particle dose delivery at flow rates as low as 20 L/min.
Median peak inspiratory flow rates achieved through the device were 45.0 L/min in mild, 45.6 L/min in moderate, and 35.4 L/min in severe COPD, with minimum peak rates reaching 28.2, 21.6, and 20.4 L/min, respectively.

Cite This Study

Chodosh et al. (2001) studied this question.

synapsesocial.com/papers/6a81516b5f017ee9d49cd280 https://doi.org/10.1089/089426801316970268

View Full Paper

Ask AI

Bookmark

Implication

Physiologic study demonstrates sufficient inspiratory flow with HandiHaler in chronic obstructive pulmonary disease, suggesting reliable drug delivery across all disease severities.

Effective Delivery of Particles with the HandiHaler® Dry Powder Inhalation System over a Range of Chronic Obstructive Pulmonary Disease Severity

Discussion

Member takes

Implication

Key Points

Cite This Study

Effective Delivery of Particles with the HandiHaler® Dry Powder Inhalation System over a Range of Chronic Obstructive Pulmonary Disease Severity

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider