Why the study?
Does CaM kinase inhibition prevent early afterdepolarization induction in rabbit ventricular myocytes?
Population
Rabbit ventricular myocytes
Comparison
Dialysis with CaM kinase inhibitor peptide AC3-I vs Dialysis with an inactive control peptide
Design
Preclinical
Authors
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CaMKII inhibition may suppress EAD-triggered arrhythmias; leaves open translation to in vivo or clinical long-QT settings.
Does CaM kinase inhibition prevent early afterdepolarization induction in rabbit ventricular myocytes?
CaM kinase facilitates early afterdepolarizations by augmenting L-type Ca2+ current, providing a cellular mechanism for long Q-T arrhythmias.
Wu et al. (1999) studied this question.
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