April 30, 1999Circulation Research
Calmodulin Kinase Inhibition Prevents Development of the Arrhythmogenic Transient Inward Current
Population
Isolated rabbit ventricular myocytes
Comparison
Prolonged action potential clamp and various… vs Shorter action potential waveform, inactive…
Design
Preclinical
Authors
Discussion
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Implication
CaMK inhibition suppresses Iti in rabbit myocytes; hypothesis-generating for CaMK-targeted antiarrhythmics, requires in vivo and clinical validation.
Structured PICO
P
Population
Isolated rabbit ventricular myocytes
I
Intervention
Prolonged action potential clamp and various inhibitors including CaM kinase inhibitory peptides, CaM inhibitory peptide, BAPTA, XIP, ryanodine, and thapsigargin
C
Comparator
Shorter action potential waveform, inactive scrambled peptide, or no inhibitor
O
Outcome
Development of the arrhythmogenic transient inward current (Iti)surrogate
Inhibition of calmodulin kinase prevents the development of arrhythmogenic transient inward currents in isolated rabbit ventricular myocytes, suggesting a role for CaM kinase in calcium-related arrhythmias.
Cite This Study
Wu et al. (1999) studied this question.